CCBM Seminar Series

Joel Bader

Assistant Professor, Whitaker Biomedical Engineering Institute 

The Johns Hopkins University

Mapping the Drosophila Network

Identifying the genes and proteins encoded in a genome identifies the components or parts list of an organism.  Biomedical advances require knowledge of how these components are connected into functional pathways.  We have participated in a landmark experimental screen to generate such a wiring diagram of the physical connections between proteins in Drosophila, an important model system for human biology (Giot, Bader et al. Science 2003).  We will show how computational analysis of the network can be applied to human disease.  Finally, we will give a preview of analysis of network robustness arising from genome-scale synthetic lethality screens in yeast in collaboration with the Boeke and Spencer labs at the School of Medicine.

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For information on disability access or to have this seminar videoconferenced to your location, contact Anne Albinak at 410-516-5310 or aalbinak@bme.jhu.edu

Tuesday, March 9, 2004
4:00-5:00pm

Room 110,
Clark Hall