Dr. Aon’s overriding appeal is the field of cellular self-organization and dynamics. His fascination for the links between organized complexity and dynamical organization goes all throughout his scientific career. Since 1989, he has made numerous contributions to pattern formation, glycolytic and mitochondrial oscillations, and the links between dynamics and geometry through fractal organization. At Johns Hopkins University, since 2001, all those interests came together as applied to heart dynamics at the subcellular, cellular and whole organ levels, working in close collaboration with Dr. Brian O’Rourke, Dr. Sonia Cortassa, Dr. Fadi G. Akar, Dr. Rai Winslow, Dr. Eduardo Marban and Dr. Gordon Tomaselli. At present, he is working on: (i) the role of oxidative stress and mitochondrial oscillations on post-ischemic arrhythmias; (ii) the main intracellular factors determining the control of inner mitochondrial membrane anion channels and reactive oxygen species (ROS) production; and (iii) mitochondrial network dynamics and ROS signaling.

Curriculum Vitae

Publications

Cortassa, S., Aon, M. A., Marban, E., Winslow, R. L. and O’Rourke, B. (2002) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J., 84: 2734-2755.

Cortassa, S., M. A. Aon, et al. (2004). "A mitochondrial oscillator dependent on reactive oxygen species." Biophys. J. 87(3): 2060-2073.

Cortassa, S., M. A. Aon, et al. (2005). "A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte." Biophys. J., submitted.