Eduardo Marbán, M.D., Ph.D

Professor of Medicine, Physiology and Biomedical Engineering, Johns Hopkins University

Dr. Eduardo Marbán is the founder and director of the Institute of Molecular Cardiobiology.

Education
Wilkes College, Wilkes-Barre, PA B.S. 1974 Mathematics
Yale University, New Haven, CT M.D. 1980 Medicine
Yale University Ph.D. 1981 Physiology
Johns Hopkins University, Baltimore, MD Board cert. 1984 Internal Medicine
Johns Hopkins University Board cert. 1987 Cardiovascular

Positions and Appointments
1976 - 1980 Ph.D. student in Physiology, Yale University. Dr. R.W. Tsien, advisor
1980 - 1981 Postdoctoral fellow, Department of Physiology, Yale University
1981 - 1984 Intern and resident, Osler Medical Service, Johns Hopkins Hospital
1983 - 1985 Research Associate, Department of Physiology, University of Maryland School of Med. (secondary appointment). Laboratory of Dr. W.G. Wier
1984 - 1985 Fellow in Cardiology, Johns Hopkins Hospital
1985 - 1988 Assistant Professor, Department of Medicine, Johns Hopkins University School of Medicine 1988 - 1991 Associate Professor 1991 - Professor of Medicine and Physiology
1999 - Michel Mirowski, M.D. Professor of Cardiology; Professor Biomedical Engineering

Awards and Honors
1986 - 1991 Research Career Development Award, N.I.H.
1989 - 1992 Cardiovascular Study Section, N.I.H. (1991 - 1992: Chairman)
1990 - American Society for Clinical Investigation
1991 - Fellow, American College of Cardiology
1992 - Association of University Cardiologists
1995 - Program Director, SCOR in Sudden Cardiac Death
1996 - 2000 Program Project Review Committee, NHLBI
1998 - Association of American Physicians
1999 - Editor-in-Chief, Circulation Research
2000 American Heart Associaton Basic Research Prize

Selected Scientific Articles Published or in Press (from a total of 216)
1. Marbán, E., Rink, T.J. Tsien, R.W. and Tsien, R.Y. Free calcium in heart muscle at rest and during contraction measured with calcium-sensitive microelectrodes. Nature 286:845-850, 1980.

2. Yue, D.T., Lawrence, J.H. and Marbán, E. Two molecular transitions influence cardiac sodium channel gating. Science 244:349-352, 1989.

3. O'Rourke, B., Backx, P. and Marbán, E. Phosphorylation-independent modulation of L-type calcium channels by magnesium-nucleotide complexes. Science 257:245-248, 1992.

4. Backx, P., Yue, D.T., Lawrence, J.H., Marbán, E. and Tomaselli, G.T. Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science 257:248-251, 1992.

5. O'Rourke, B., Ramza, B.M. and Marbán, E. Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells. Science 265:962-966, 1994.

6. Gao, W.D., Atar, D., Liu, Y., Perez, N.G., Murphy, A.M. and Marbán, E. Role of troponin I proteolysis in the pathogenesis of stunned myocardium. Circulation Research 80:393-399, 1997.

7. Johns, D.C., Nuss, H.B. and Marbán, E. Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant negative Kv4.2 constructs. Journal of Biological Chemistry 272:31598-31603, 1997.

8. Gao, W.D., Perez, N.G., and Marbán, E. Calcium cycling and contractile activation in intact mouse cardiac muscle. Journal of Physiology 507:175-184, 1998.

9. Liu, Y., Sato, T., O'Rourke, B. and Marbán, E. Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation 97:2463-2469, 1998.

10. Sato, T., O'Rourke, B. and Marbán, E. Modulation of mitochondrial ATP-dependent potassium channels by protein kinase C. Circulation Research 83:110-114, 1998.

11. Perez, N.G., Gao, W.D. and Marbán, E. Novel myofilament calcium-sensitizing property of xanthine oxidase inhibitors. Circulation Research 83:423-430, 1998.

12. Kloner, R.A., Bolli, R., Marbán, E., Reinlib, L., Braunwald, E. and Participants. Medical and cellular implications of stunning, hibernation and preconditioning, an NHLBI workshop. Circulation 97:1848-1867, 1998.

13. O'Rourke, B., Kass, D.A., Tomaselli, G.F., Kaab, S., Tunin, R. and Marbán, E. Mechanisms of altered excitation- contraction coupling in canine tachycardia-induced heart failure. I. Experimental studies. Circulation Research 84:562-570, 1999.

14. Winslow, R.L., Rice, J., Jafri, S., Marbán, E. and O'Rourke, B. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. II. Model studies. Circulation Research 84:571-586, 1999.

15. Perez, N.G., Hashimoto, K., McCune, S., Altschuld, R.A. and Marbán, E. Origin of contractile dysfunction in heart failure: calcium cycling versus myofilaments. Circulation 99:1077-1083, 1999.

16. Gao, W.D., Perez, N.G., Seidman, C.E., Seidman, J.G. and Marbán, E. Altered excitation-contraction coupling in mutant mice and familial hypertrophic cardiomyopathy. Journal of Clinical Investigation 103:661-666, 1999.

17. Perez, N.G., Marbán, E. and Cingolani, H.E. Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning. Cardiovascular Research 42:636-643, 1999.

18. Johns, D.C., Marx, R., Mains, R.E. and Marbán, E. Inducible genetic suppression of neuronal activity. Journal of Neuroscience

19:1691-1697, 1999. 19. Nuss, H.B., Marbán, E. and Johns, D. Overexpress of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes. Journal of Clinical Investigation 103:889-896, 1999.

20. Hoppe, U.C., Johns, D.C., Marbán, E. and O'Rourke, B. Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward potassium current on the guinea-pig action potential. Circulation Research 84:964-972, 1999.

21. Murphy, A.M., Kögler, H., Georgakopoulos, D., McDonough, J.L., Kass, D.A., Van Eyk, J.E. and Marbán, E. Transgenic mouse model of stunned myocardium. Science 287:488-491, 2000.

22. Hoppe, U.C., Marbán, E. and Johns, D.C. Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor. Molecular Therapy 1:159-164, 2000.

23. Hoppe, U.C., Marbán, E. and Johns, D.C. Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer. Journal of Clinical Investigation 105:1077-1084, 2000.

24. Donahue, J.K., Heldman, A.W., Frazier, H., McDonald, A.D., Miller, J.M., Rade, J.J., Eschenhagen, T. and Marbán, E. Focal modification of electrical conduction in the heart by viral gene transfer. Nature Medicine 6:1395-1398, 2000.

25. Murphy, A.M., Kögler, H. and Marbán, E. A mouse model of myocardial stunning. Molecular Medicine Today 6:330-331, 2000.

Contact Information
Phone:
Email: marban@jhmi.edu