Director : Center for Cardiovascular Bioinformatics and Modeling
Director: The Institute for Computational Medicine
Director : The Biomedical Engineering Graduate Program
Associate Director : The Whitaker Biomedical Engineering Institute
Primary Appointment : Professor, Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Secondary Appointments :

Department of Computer Science, The Whiting School of Engineering

Department of Electrical Engineering, The Whiting School of Engineering

Department of Medicine, The Johns Hopkins University School of Medicine

Division of Biomedical Information Sciences, Johns Hopkins University School of Medicine

Contact Information

Address:

315 Hackerman Hall
Johns Hopkins University
3400 N. Charles St.
Baltimore MD 21218

Phone: (443) 519-2204
FAX: (410) 516-5294
E-mail: rwinslow@jhu.edu

Curriculum Vitae

Research Interests:

Computational modeling of intracellular signaling, metabolism and electrical excitability in cardiac myocytes.

Integrative modeling of cardiac function in health and disease

Biomedical data representation and database design

Grid-computing and data-sharing

Current Projects:

The CardioVascular Research Grid (www.cvrgrid.org)

The Systems Biology of Sudden Cardiac Death (www.icm.jhu.edu/r33/)

The Proteomics of Adaptation to Ischemia and Hypoxia in Heart, Lung, and Blood (www.proteomics.jhu.edu)

Pathobiology of Cardiac Dyssynchrony & Resynchronization

Mitochondrial Function in Ischemic Heart Disease

Publications:

Tanskanen A. J., J. L. Greenstein, A. Chen, S. X. Sun, R. L. Winslow (2007). "Protein Geometry and Placement in the Cardiac Dyad Influence Macroscopic Properties of Calcium-Induced Calcium Release." Biophys J, 92(10): 3379-3396.

Cortassa S., M. A. Aon, B. O'Rourke, R. Jacques, H. J. Tseng, E. Marban, R. L. Winslow (2006). "A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte." Biophys J., 91(4): 1564-1589.

Greenstein J. L., R. Hinch, R. L. Winslow (2006). "Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte." Biophys J., 90(1): 77-91.

Tanskanen A.J., J. L. Greenstein, B. O'Rourke, R. L. Winslow (2005). "The Role of Stochastic and Modal Gating of Cardiac L-type Ca2+ Channels on Early After-Depolarizations." Biophys J., 88(1): 85-95.

Hinch R., J. L. Greenstein, A.J. Tanskanen, L. Xu, R. L. Winslow (2004). "A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes." Biophys J., 87(6): 3723-3736.

Greenstein J. L., R. L. Winslow (2002). "An Integrative Model of the Cardiac Ventricular Myocyte Incorporating Local Control of Ca2+ Release." Biophys J., 83(6): 2918-45.

Select Presentations:

"High-Performance Computing and Integrative Modeling of Biological Systems." National Academy of Sciences, Symposium on Potential Impacts of High-End Capability Computing, September 22, 2008. (PDF) (MOV)

"Multi-Scale Modeling of Calcium Signaling in the Cardiac Dyad." Institute for Integrative Systems Biology, Georgia Institute of Technology, March 28, 2008.

"Multi-Scale Modeling of Cardiac Function in Health and Disease." Harvard University School of Engineering, October 24, 2007.

"Integrative Modeling of Cardiac Function Health and Disease." Summit on Systems Biology 2007. Virginia Commonwealth University, Richmond, VA, June 4-7, 2007. (PDF)

"Computational Medicine in Heart Disease." Predictive Health Symposium, Emory University School of Medicine, December 18-19, 2006.

"Multi-Scale Modeling of Cardiac EC Coupling." Distinguished Lecturer Series, The Cardiovascular Research and Technology Institute, University of Utah, June 1, 2006. (PDF)