Director : Center for Cardiovascular Bioinformatics and Modeling
Director: The Institute for Computational Medicine
Director : The Biomedical Engineering Graduate Program
Associate Director : The Whitaker Biomedical Engineering Institute
Primary Appointment : Professor, Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Secondary Appointments :

Department of Computer Science, The Whiting School of Engineering

Department of Electrical Engineering, The Whiting School of Engineering

Department of Medicine, The Johns Hopkins University School of Medicine

Division of Biomedical Information Sciences, Johns Hopkins University School of Medicine

Research Interests

Statistical modeling and analysis of cardiovascular gene and protein expression data

Ontologies, databases and web services for supporting biological data mining

Computational modeling of signal transduction, mitochondrial energetics, ion channel function, and intracellular calcium dynamics in cardiac myocytes and vascular endothelial cells

Magnetic resonance imaging and modeling of cardiac ventricular anatomic structure

Measurement and modeling of electrical conduction in the cardiac ventricles

Contact Information

Address:

315 Computational Science & Engineering Building

Johns Hopkins University

3400 N. Charles St.

Baltimore MD 21218

Phone: (410) 516-5417 / FAX: (410) 516-5294 / Cell: (443) 850-6876

E-mail: rwinslow@jhu.edu

Curriculum Vitae

Publications

Peer Reviewed Articles

Cao, Y., M. I. Miller, S. Mori, R. L. Winslow and L. Younes (2006). "Diffeomorphic registration of diffusion tensor magnetic resonance images." IEEE Trans. Med. Imag. submitted.

Cortassa, S., M. Aon, R. Jacques, R. L. Winslow and B. O. O’Rourke (2006). "Sensitivity analysis of an integrated model of the cardiomyocyte." Am. J. Physiol. submitted.

Gao, Z., R. L. Winslow and G. Tomaselli (2006). "Key pathways responsible for heart failure development revealed by gene networks correlated with cardiac remodeling." Physiol. Genomics submitted.

Xu, L., D. Geman and R. L. Winslow (2006). "Large-scale integration of cancer microarray data identifies a robust common cancer signature." Bioinformatics submitted.

Anderson, T. J., I. Chernysheva, D. Geman, C. V. Dang and R. L. Winslow (2006). "Application of a novel machine learning algorithm to 2D difference gel electrophoresis data: towards the discovery of robust protein biomarkers in disease." Proteomics submitted.

Tanskanen, A. J., J. L. Greenstein, M. Chen, S. X. Sun and R. L. Winslow (2006). "Calcium Dynamics in the Cardiac Diad: Roles of Signaling Noise and Protein Structure." Biophys. J. submitted.

Tanskanen, A. J. and R. L. Winslow (2006). "Integrative Structurally-detailed model of calcium dynamics in the cardiac diad." SIAM Journal of Multi-Scale Modeling and Simulation.

Winslow, R. L., A. J. Tanskanen, M. Chen and J. L. Greenstein (2006). "Multi-Scale Models of Calcium Signaling in the Cardiac Dyad." Ann. N. Y. Acad. Sci. 1080: 362-375.

Ideker, T., R. L. Winslow and D. A. Lauffenburger (2006). "Bioengineering and systems biology." Ann. Biomed. Eng. 34(2): 257-264.

Yang, C. G., S. J. Granite, J. Van Eyk and R. L. Winslow (2005). "Mascot HTML and XML Parser: An implementation of a novel object model for protein identification." Proteomics.

Granite, S. J., C. G. Yang, A. Ali, D. Robinson, J. Van Eyk and R. L. Winslow (2005). "PROTEIN-DB2: a database for storing and querying primary proteomic data and subsequent analyses." Proteomics.

Cortassa, S., M. A. Aon, B. O'Rourke, R. Jacques, H. J. Tseng, E. Marban and R. L. Winslow (2005). "A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte." Biophys. J. epub.

Helm, P. A., L. Younes, F. M. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller and R. L. Winslow (2005). "Evidence of Structural Remodeling in the Dyssynchronous Failing Heart." Circ. Res. 98(1): 1-3.

Hinch, R., J. L. Greenstein and R. L. Winslow (2005). "Multi-Scale Models of Local Control of Calcium Induced Calcium Release." Prog. Mol. Biol. Biophys. 90(1-3): 136-150.

Gao, Z., H. Xu, D. DiSilvestre, V. L. Halperin, R. Tunin, Y. Tian, W. Yu, R. L. Winslow and G. F. Tomaselli (2005). "Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure." J. Mol. Cell. Cardiol 40(1): 76-86.

Greenstein, J. L., R. Hinch and R. L. Winslow (2005). "Mechanisms Underlying Local Control of Excitation-Contraction Coupling in an Efficient Model of the Cardiac Ventricular Myocyte." Biophys. J. 90(1): 77-91.

Cao, Y., M. I. Miller, R. L. Winslow and L. Younes (2005). "Large Deformation Diffeomorphic Metric Mapping of Vector Fields." IEEE Trans Med. Imag. 24(9): 1216-1230.

Helm, P. A., H. J. Tseng, L. Younes, E. McVeigh and R. L. Winslow (2005). "Ex Vivo 3D Diffusion Tensor Imaging and Quantification of Cardiac Laminar Structure." Mag. Res. Med. 54(4): 850-859.

Xu, L., A. C. Tan, D. Q. Naiman, D. Geman and R. L. Winslow (2005). "Robust Prostate Cancer Marker Genes Emerge from Direct Integration of Inter-Study Microarray Data." Bioinformatics 21(20): 3905-3911.

Tan, A. C., D. Q. Naiman, L. Xu, R. L. Winslow and D. Geman (2005). "Simple Decision Rules for Classifying Human Cancers from Gene Expression Profiles." Bioinformatics 21(20): 3896-3904.

Helm, P. A., M. F. Beg, M. I. Miller and R. L. Winslow (2005). "Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging." Annals NY Acad Sci. 1047: 296-307.

Winslow, R. L., S. Cortassa and J. L. Greenstein (2005). "Using Models of the Myocyte for Functional Interpretation of Cardiac Proteomic Data." J. Physiol. 563(1): 73-81.

Tanskanen, A. J., J. L. Greenstein, B. O'Rourke and R. L. Winslow (2005). "The Role of Stochastic and Modal Gating of Cardiac L-type Ca2+ Channels on Early After-Depolarizations." Biophys. J. 88(1): 85-95.

Winslow, R. L. and J. L. Greenstein (2004). "The Ongoing Journey to Understand Heart Function Through Integrative Modeling." Circ. Res. 95(12): 1135-1136.

Beg, M. F., P. A. Helm, E. McVeigh, M. I. Miller and R. L. Winslow (2004). "Computational cardiac anatomy using MRI." Mag. Res. Med. 52(5): 1167-1174.

Hinch, R., J. L. Greenstein, A. J. Tanskanen, L. Xu and R. L. Winslow (2004). "A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes." Biophys. J. 87(6): 3723-3736.

Cortassa, S., M. A. Aon, R. L. Winslow and B. O'Rourke (2004). "A mitochondrial oscillator dependent on reactive oxygen species." Biophys. J. 87(3): 2060-2073.

Iyer, V., R. Mazhari and R. L. Winslow (2004). "A computational model of the human left-ventricular epicardial myocyte." Biophys. J. 87(3): 1507-1525.

Geman, D., C. D'Avignon, D. Q. Naiman and R. L. Winslow (2004). "Classifying Gene Expression Profiles from Pairwise mRNA Comparisons." Stat. Appl. Genet. Mol. Biol. 3(1): Article 19.

Greenstein, J. L., A. J. Tanskanen and R. L. Winslow (2004). "Modeling the Actions of b-adrenergic Signaling on Excitation-Contraction Coupling Processes." Ann. N. Y. Acad. Sci. 1015: 16-27.

Armoundis, A. A., I. A. Hobai, G. F. Tomaselli, R. L. Winslow and B. O'Rourke (2003). "Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts." Circ. Res. 93(1): 46-53.

Yung, C. K., V. L. Halperin, G. F. Tomaselli and R. L. Winslow (2003). "Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes." Genomics 83(2): 281-297.

dos Remedios, C. G., C. C. Liew, P. D. Allen, R. L. Winslow, J. Van Eyk and M. J. Dunn (2003). "Genomics, proteomics and bioinformatics of human heart failure." J. Muscle Res. Cell Motil 24(4-6): 251-260.

Winslow, R. L. and M. S. Boguski (2003). "Genome informatics: Current status and future prospects." Circ. Res. 92(9): 953-961.

Beg, M. F., M. I. Miller, A. Trouve and L. Younes (2003). "Computing Large Deformation Metric Mappings via Geodesics Flows of Diffeomorphisms." International Journal of Computer Vision 61(2): 139-157.

Cortassa, S., M. A. Aon, E. Marban, R. L. Winslow and B. O'Rourke (2002). "An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics." Biophys. J. 84(4): 2734-2755.

Greenstein, J. L. and R. L. Winslow (2002). "An Integrative Model of the Cardiac Ventricular Myocyte Incorporating Local Control of Ca2+ Release." Biophys. J. 83(6): 2918-2945.

Bober, M., K. Wiehe, C. K. Yung, S. T. O., M. Lin, W. A. Baumgartner Jr. and R. L. Winslow (2002). "CaGE: Cardiac Gene Expression Knowledgebase." Bioinformatics 18(7): 1013-1014.

Mazhari, R., H. B. Nuss, A. A. Armoundis, R. L. Winslow and E. Marban (2002). "Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval." J. Clinic. Invest. 109(8): 1083-1090.

Mazhari, R., J. L. Greenstein, R. L. Winslow, E. Marban and H. B. Nuss (2001). "Molecular Interactions Between Two Long-QT Syndrome Gene Products, HERG and KCNE2, Rationalized by In Vitro and In Silico Analysis." Circ. Res. 89(1): 33-38.

Winslow, R. L., J. L. Greenstein, G. F. Tomaselli and B. O'Rourke (2001). "Computational Models of the Failing Myocyte: Relating Altered Gene Expression to Cellular Function." Phil. Trans. Roy. Soc. A 359(1783): 1187-1200.

Winslow, R. L., D. F. Scollan, J. L. Greenstein, C. K. Yung, W. A. Baumgartner Jr., G. Bhanot, D. Gresh and B. Rogowitz (2001). "Mapping, Modeling and Visual Exploration of Structure-Function Relationships in the Heart." IBM Systems Journal 40(2): 342-359.

Winslow, R. L., D. F. Scollan, A. Holmes, C. K. Yung, J. Zhang and M. S. Jafri (2000). "Electrophysiological modeling of cardiac ventricular function: from cell to organ." Ann. Rev. of Biomed. Eng. 2: 119-155.

Scollan, D. F., J. Zhang, A. Holmes and R. L. Winslow (2000). "Reconstruction of cardiac ventricular geometry and fiber orientation using magnetic resonance imaging." Annals of BME 28(8): 934-944.

Greenstein, J. L., R. Wu, S. Po, G. F. Tomaselli and R. L. Winslow (2000). "Role of the Calcium-Independent Transient Outward Current I (to1) in Shaping Action Potential Morphology and Duration." Circ. Res. 87(11): 1026-1033.

Holmes, A., D. F. Scollan and R. L. Winslow (2000). "Direct histological validation of diffusion tensor MRI in formaldehyde-fixed myocardium." Mag. Res. Med. 44(1): 157-161.

Rice, J. J., M. S. Jafri and R. L. Winslow (2000). "Modeling short-term interval-force relations in cardiac muscle." Am. J. Physiol. 278(3): H913-H931.

Kohl, P., D. Noble, R. L. Winslow and P. Hunter (2000). "Computational modeling of biological systems: tools and visions." Phil. Trans.: Mathematical, Physical and Engineering Sciences 358(1766): 579-610.

Steinmetz, P. and R. L. Winslow (1999). "Optimal detection of flash intensity differences using rod photocurrent observations." Neural Computation 11(5): 1097-1111.

Rice, J. J., M. S. Jafri and R. L. Winslow (1999). "Modeling gain and gradedness of Ca2+ release in the functional unit of the cardiac diadic space." Biophys. J. 77(4): 1871-1884.

Rice, J. J., R. L. Winslow and W. C. Hunter (1999). "Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses." Am. J. Physiol. - Heart and Circ. 276(5): H1734-H1884.

Irvine, L., M. S. Jafri and R. L. Winslow (1999). "Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation." Biophys. J. 76(4): 1868-1885.

Winslow, R. L., J. J. Rice, S. Jafri, E. Marban and B. O'Rourke (1999). "Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies." Circ. Res. 84(5): 571-586.

Winslow, R. L., J. Rice and S. Jafri (1998). "Modeling the cellular basis of altered excitation-contraction coupling in heart failure." Prog. Biophys. Mol. Biol. 69(2-3): 497-514.

Rice, J. J., R. L. Winslow, J. Dekanski and E. McVeigh (1998). "Model studies of the role of mechano-sensitive currents in the generation of cardiac arrhythmias." J. Theo. Biol. 190(4): 295-312.

Jafri, M. S., J. J. Rice and R. L. Winslow (1998). "Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load." Biophys. J. 74(3): 1149-1168.

Rice, J. J., M. S. Jafri and R. L. Winslow (1998). "Modeling short-term interval-force relations in cardiac muscle." Ann. N. Y. Acad. Sci. 853: 345-349.

Scollan, D. F., A. Holmes, R. L. Winslow and J. Forder (1998). "Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging." Am. J. Physiol. - Heart and Circ. 275: H2308-H2318.

Zhang, H., R. L. Winslow and A. V. Holden (1998). "Re-entrant excitation initiated in models of inhomogeneous atrial tissue." J. Theo. Biol. 191(3): 279-287.

Kohl, P., A. Varghese, J. Dekanski, D. Noble and R. L. Winslow (1996). "Computational study of the impact of cardiac mechanosensitive fibroblasts on heart rhythm." Exp. Clin. Cardiol. 1(2): 80-86.

Noble, D., Y. LeGuennec and R. L. Winslow (1996). "Functional roles of sodium-calcium exchange in normal and abnormal cardiac rhythm." Ann. N. Y. Acad. Sci. 779: 480-488.

Lai, Y. C. and R. L. Winslow (1995). "Geometric properties of the chaotic saddle responsible for supertransients in spatiotemporal chaotic systems." Physical Review Letters 74(26): 5208-5211.

Winslow, R. L., D. Cai, A. Varghese and Y. C. Lai (1995). "Generation and propagation of normal and abnormal pacemaker activity in network models of cardiac sinus node and atrium." Chaos, Solitons, and Fractals 5(3-4): 491-512.

Lai, Y. C., R. L. Winslow and M. B. Sachs (1994). "A model of selective processing of auditory-nerve inputs by stellate cells of the antero-ventral cochlear nucleus." Journal of Computational Neuroscience 1(3): 167-194.

Lai, Y. C. and R. L. Winslow (1994). "Extreme sensitive dependence on parameters and initial conditions in spatio-temporal chaotic dynamical systems." Physica D: Nonlinear Phenomena 74(3-4): 353-371.

Lai, Y. C., R. L. Winslow and M. B. Sachs (1994). "The functional role of excitatory and inhibitory interactions in chopper cells of the antero-ventral cochlear nucleus." Neural Computation 6(6): 1126-1139.

Lai, Y. C. and R. L. Winslow (1994). "Fractal basin boundaries in coupled map lattices." Physical Review E 50(5): 3470-3473.

Varghese, A. and R. L. Winslow (1994). "Dynamics of abnormal pacemaking activity in cardiac Purkinje fibers." J. Theo. Biol. 168(4): 407-420.

Cai, D., R. L. Winslow and D. Noble (1994). "Effects of gap junction conductance on dynamics of sinoatrial node cells: two-cell and large-scale network models." IEEE Trans. BME 41(3): 217-231.

Lai, Y. C. and R. L. Winslow (1994). "Riddled parameter space in spatiotemporal chaotic dynamical systems." Physical Review Letters 72(11): 1640-1643.

Varghese, A. and R. L. Winslow (1993). "Dynamics of the calcium subsystem in cardiac Purkinje fibers." Physica D: Nonlinear Phenomena 68(3-4): 364-386.

Winslow, R. L., A. Kimball, A. Varghese and D. Noble (1993). "Simulating cardiac sinus and atrial network dynamics on the Connection Machine." Physica D: Nonlinear Phenomena 64(1-3): 281-298.

Cai, D., Y. C. Lai and R. L. Winslow (1993). "Complex dynamics in coupled cardiac pacemaker cells." Physical Review Letters 71(15): 2501-2504.

Winslow, R. L., D. Noble, A. Varghese, C. Adlakha and A. Hoythya (1993). "Generation and propagation of ectopic beats induced by spatially localized Na-K pump inhibition in atrial network models." Proc Biol Sci. 254 (1339): 55-61.

Winslow, R. L. and A. G. Knapp (1991). "Dynamic models of the retinal horizontal cell network." Prog. Biophys. Molec. Biol. 56(2): 107-133.

Winslow, R. L. and S. Ma (1990). "Bifurcation analysis of nonlinear retinal horizontal cell models: II. Network properties." J. Neurophysiol. 64(1): 248-261.

Sachs, M. B., R. L. Winslow and B. Sokolowski (1989). "A computational model for rate-level functions from cat auditory-nerve fibers." Hearing Res. 41(1): 61-69.

Winslow, R. L. and R. F. Miller (1989). "A theoretical and experimental study of the effects of non-uniform membrane resistance on the shape of single-cell charging curves." Neurosci. 29(3): 761-771.

Winslow, R. L., R. F. Miller and T. E. Ogden (1989). "Functional role of spines in the retinal horizontal cell network." Proc. Natl. Acad. Sci. USA 86(1): 387-391.

Winslow, R. L. (1989). "Bifurcation analysis of nonlinear retinal horizontal cell models: I. Properties of isolated cells." J. Neurophysiol. 62(3): 738-749.

Winslow, R. L. and M. B. Sachs (1988). "Single-tone intensity discrimination based on auditory-nerve rate responses in backgrounds of quiet, noise, and with stimulation of the crossed olivocochlear bundle." Hearing Res. 35(2-3): 165-189.

Winslow, R. L. and M. B. Sachs (1987). "Effect of electrical stimulation of the crossed olivocochlear bundle on auditory nerve response to tones in noise." J. Neurophysiol. 57(4): 1002-1021.

Conference Proceedings

Cao, Y., M. I. Miller, R. L. Winslow and L. Younes (2005). Large Deformation Diffeomorphic Metric Mapping of Fiber Orientations. 10th IEEE International Conference on Computer Vision, Beijing, China.

Beg, M. F., M. I. Miller, A. Trouve and L. Younes (2003). The Euler--Lagrange Equations for Interpolating Sequence of Landmark Datasets. 6th International Conference Medical Image Computing and Computer-Assisted Intervention (MICCAI), Montréal, Canada, Springer-Verlag.

Winslow, R. L., P. A. Helm, W. A. Baumgartner Jr., S. Peddi, T. Ratnanather, E. McVeigh and M. I. Miller (2002). Imaging-Based Integrative Models of the Heart: Closing the Loop Between Experiment and Simulation. Novartis Foundation Symposium 247 on In Silico Simulation of Biological Processes, London, UK, John Wiley & Sons, LTD.

Gresh, D., B. Rogowitz, R. L. Winslow, D. F. Scollan and C. K. Yung (2000). WEAVE: A System for Visually Linking 3-D and Statistical Visualizations Applied to Cardiac Simulation and Measurement Data. Visualization 2000, Salt Lake City, Utah.

Demir, S. S., B. O'Rourke, G. F. Tomaselli, E. Marban and R. L. Winslow (1996). Action Potential Variation in Canine Ventricle: A Modeling Study. Computers in Cardiology, Indiannapolis, IN, IEEE Press.

Irvine, L. and R. L. Winslow (1996). Numerical Studies of Use-Dependent Block of Cardiac Sodium Channels by Quinidine on Spiral Wave Reentry. Computers in Cardiology, Indianapolis, USA, IEEE.

Winslow, R. L., D. Cai and Y. C. Lai (1994). Factors controlling generation and propagation of pacemaker potentials in network models of mammalian SA node. Supercomputer, Washington, DC.

Varghese, A. and R. L. Winslow (1994). Ion accumulation and arrhythmogenesis in networks of cardiac cells. Computers in Cardiology, Washington, DC, IEEE Computer Society Press.

Winslow, R. L. (1994). Modeling intercellular interaction and mechano-electrical effects in large networks of cardiac cells. 18th Meeting of the European Working Group in Cardiac Cellular Electrophysiology, Arnhem, The Netherlands.

Winslow, R. L., D. Cai and Y. C. Lai (1994). Network models of the SA node. Second IFAC Symposium on Modeling and Control in Biomedical Systems, Galveston, TX.

Winslow, R. L. and A. Varghese (1994). Modeling the functional role of SA node-atrial interdigitation. Computers in Cardiology, Bethesda, MD, IEEE Computer Society Press.

Cai, D., Y. C. Lai and R. L. Winslow (1993). Periodicity, quasiperiodicity, and chaos in coupled cardiac pacemaker cells. The International Society for Optical Engineering International Symposium on Chaos in Biology and Medicine (SPIE), San Diego, California.

Noble, D., R. L. Winslow, A. Kimball and A. Varghese (1992). Modeling the heart on the Connection Machine. Fourth International Exhibition and Conference on High Performance Computing.

Cai, D., R. L. Winslow and D. Noble (1992). Effects of Gap Junction Conductance on Oscillation Properties of Coupled Sino-Atrial Node Cells. Computers in Cardiology, Durham, NC.

Noble, D., J. C. Denyer, R. L. Winslow and A. Kimball (1991). Modeling of cardiac rhythm: From single cells to massive networks. 18th International Symposium on Cardiovascular Electrophysiology, Korean Academy of Medical Sciences.

Kimball, A. and R. L. Winslow (1990). Modeling the Retinal Horizontal Cell Layer on a Massively Parallel Processor: A Detailed Neural Network Model. Second IEEE Symposium on Parallel and Distributed Processing (SPDP), Dallas, TX.

Book Chapters

Winslow, R. L., J. L. Greenstein, et al. (2007). Biophysical Models of the Cardiovascular System. Systems Biology Volume II: Networks, Models, and Applications. I. R. a. G. Stephanopoulos, Oxford University Press: 265-296.

Winslow, R. L., J. L. Greenstein and P. A. Helm (2005). Biophysical Models of the Cardiovascular System. Systems Biology. I. R. a. G. Stephanopoulos, Springer Verlag.

Winslow, R. L., R. Hinch and J. L. Greenstein (2005). Mechanisms and Models of Cardiac Excitation-Contraction Coupling. Synapses and Muscle. J. Sneyd and A. Friedman, Springer-Verlag. in press.

Winslow, R. L. (2004). Proteomics. The Wiley Interscience Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. L. B. Jorde, P. F. R. Little, M. Dunn and S. Subramaniam. Chichester, UK, John Wiley and Sons, Ltd.: 3700.

Winslow, R. L. (2003). Modeling Cardiac Function. Complex Systems in Biomedicine. T. Deisboeck, T. Kepler and Y. Kresh. New York, Kluwer Academic Press.

Winslow, R. L., Ed. (2003). Cellular Models. Databasing the Brain: Data to Knowledge, John Wiley & Sons, Ltd.

Bober, M., P. Delmar, S. Szak, U. Karaoz, J. White, J. Hudson, M. Boguski, G. F. Tomaselli and R. L. Winslow (2001). Gene expression in human heart failure: Microarray analysis of dilated cardiomyopathy. Currents in Computational Molecular Biology. N. El-Manrouk, T. Lengauer and D. Sankoff. Montreal, Les Publications CRM: 171-172.

Bober, M. B., P. Delmar, S. T. Szak, U. Karaoz, J. A. White, J. Hudson, M. Boguski, G. F. Tomaselli and R. L. Winslow (2001). The Human Cardiac Gene Expression Knowledgebase. Currents in Computational Molecular Biology. N. El-Manrouk, T. Lengauer and D. Sankoff. Montreal, Les Publications CRM: 239-240.

Noble, D. and R. L. Winslow (1994). Reconstructing the heart: Network models of SA node-atrial interactions. Computational Biology of the Heart. A. V. Panfilov and A. V. Holden, John Wiley and Sons, Ltd.

Noble, D., H. F. Brown and R. L. Winslow (1993). Propagation of pacemaker activity: Interaction between pacemaker cells and atrial tissues. Pacemaker Activity and Intercellular Communication. W. Giles and J. D. Huizinga, CRC Press.

Noble, D., J. C. Denyer, H. F. Brown, R. L. Winslow and A. Kimball (1992). Cardiac pacemaker activity: From single cells to modelling the heart. Heart Function in Health and Disease. B. Ostadal, Kluwer Academic Press.

Noble, D., J. C. Denyer, H. F. Brown, R. L. Winslow and A. Kimball (1992). Modeling of cardiac rhythm: from single cells to massive networks. Coupled Oscillating Neurons. J. G. Taylor and C. L. T. Mannion. New York, Springer-Verlag: 145.

Winslow, R. L., P. E. Barta and M. B. Sachs (1987). Rate coding in the auditory-nerve. Auditory Processing of Complex Sounds. C. S. Watson and W. Yost. Hillsdale, Lawrence Erlbaum Associates: 212-224.

Sachs, M. B., R. L. Winslow and C. C. Blackburn (1986). Representation of speech in the auditory periphery. Auditory Function. G. M. Edelman, W. E. Gall and W. M. Cowan. New York, John Wiley & Sons: 747-774.

Presentations

"Simple decision rules for classifying human cancers from gene expression profiles", The 13th Annual International Conference on Intelligent Systems for Molecular BiologyDetriot, MI, June 25-29, 2005

"Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging", Third Fairberg Cardiac WorkshopSintra, Portugal, January 15-19, 2005 [PDF] [HTML] [PPT]

"Multi-Scale Modeling of Cardiac Electrophysiological Function", The Whitaker Foundation Biomedical Engineering Research ConferenceLa Jolla, CA, August 12-15, 2004 [PPT] [HTML]

"Ca-Induced Ca-Release in the Cardiac Myocyte: From Micrscopic Channel Gating to macroscopic Cell Behavior", Pacific Northwest Symposium on Systems Biology Richland WA, June 16-18, 2004 [PPT] [HTML] [PDF]

"A Systems Approach to Understanding Sudden Cardiac Death inHeart Failure", IBM Life Sciences ForumIBM Pallisades Executive Conference Center, May 17-19, 2004 [PPT] [PDF]

"Integrative Models of the Cardiac Ventricular Myoycte: From Mmicroscopic Channel Gating to Macroscopic Cell Behavior", Department of Biomedical Informatics, Columbia UniversityNew York NY, January 26, 2004 [PPT] [HTML]

"Mechanisms and Models of Cardiac Excitation-Contraction Coupling", The Mathematical Biosciences InstituteColumbus, OH, March 2, 2004 [HTML] [PPT]

"Multi-Scale Analysis of Cardiac Function: From data to Models", Microarray Data Generation, Integration, Visualization and AnalysisBethesda, MD, March 3, 2004 [PDF] [PPT] [HTML]

"Information Flow at the Systems Level: Organization and Modeling of Experimental Data Across Multiple Scales of Biological Analysis", DIMACS Conference on Information Flow From the Gene to Organism Level,Bethesda MD, November 4-5, 2003 [HTML] [PPT] [PDF]

"Modeling the Actions of b1-adrenergic signaling on excitation-contraction coupling processes", Cardiac Engineering: From Genes and Cells to Structure and Function, 2nd Larry & Horti Fairberg WorkshopSicily, Italy, September 20-24, 2003 [PPT] [PDF] [HTML]

"Relating Relating "microscopic" properties of calcium-induced calcium-release to "macroscopic" function of the ventricular myocyte", Computational Cell Biology 2Cranwell Resort, MA, March 22-24, 2003 [PPT]

"Systems Biology: A Necessary Methodology for Understanding Heart Failure", 2003 Symposium on Systems BiologyInstitute for Systems Biology, Seattle WA, April 14, 2003 [PPT] [PDF] [HTML]

"Relating "microscopic" properties of calcium-induced calcium-release to "macroscopic" function of the ventricular myocyte", The Richard Skalak Memorial LectureDepartment of Biomedical Engineering, the University of California San Diego, March 15, 2002 [HTML] [PDF] [PPT]

"An Integrative Model of the Cardiac Ventricular Myocyte Incorporating Local-Control of JSR Ca2+ Release", Raimond L. Winslow and Joseph L. Greenstein. DIMACS Workshop on Complexity in Biosystems: Innovative Approaches at the Interface of Experimental Modeling and Computational Simulation Rutgers University, Piscataway, NJ, April 8-10, 2002 [HTML] [PDF] [PPT]

"Models of ventricular anatomy and electrical propagation derived from diffusion tensor MRI", David Scollan, PhD Thesis DefenseDepartment of Biomdical Engineering, The Johns Hopkins University School of Medicine, April 20, 2002 [HTML] [PDF]

"Local control of calcium release and it's implications for myocyte properties", Joseph Greenstein, PhD Thesis DefenseDepartment of Biomedical Engineering, The Johns Hopkins University, April 27, 2002 [PDF] [PPT] [HTML]

"Regulation of action potential duration in a ventricular myocyte model incorporating local-control of JSR Ca2+ release", Satellite Symposium of the 41st Annual Conference of Japanese Society for Medical and Biomedical EngineeringTokyo University, Tokyo, Japan, May 8, 2002 [PDF] [PPT] [HTML]

"Integrative anatomical and electrophysiological models of the cardiac ventricles", The 41st Annual Conference of Japanese Society for Medical and Biomedical Engineering Kyoto International Conference Hall, Kyoto, Japan, May 10, 2002 [PDF] [PPT] [HTML]

"Computer Modeling of the Ventricular Myocyte and Drug-Channel Interactions", The 3rd Annual CBI Predictive Toxicology ConferenceCrown Plaza Hotel, Philadelphia PA, June 13-14, 2002 [PDF] [PPT] [HTML]

"Technology Innovation Project 3: Informatics and Modeling", The Inaugural JHU-NHLBI Proteomics Center SymposiumBaltimore MD, November 8, 2002 [PDF] [PPT] [HTML]

"Relating Microscopic Properties of Calcium-Induced Calcium Release to Macroscopic Function of the Myocyte", Cardiac Mini-SymposiumUniversity of Oxford, December 6, 2002 [PPT] [PDF] [HTML]

"Computational Models of the Failing Heart: Relating Altered Gene Expression to Myocyte Function", Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, February 23, 2001 [HTML] [PPT]

"Integrative Modeling of Biological Systems: Relating Altered Gene Expression to Cell and Tissue Function", Department of Mathematics, the Johns Hokpins University, April 5, 2001 [HTML] [PPT]

"Relating Local Calcium Signaling to Cardiac Cellular Function in the Normal and Failing Heart", Thesis Proposal (J. Greenstein)Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, 2001 [HTML] [PPT]

"Computer Modeling of Excitation-Contraction Coupling", Calcium SymposiumGuidant Corporation, May 23, 2001 [HTML] [PPT]

"A Heart Failure Knowledgebase Combining Experimental Data with Tools for Integrative Biological Modeling", Raimond L. Winslow, William Baumgartner Jr., Patrick Helm, David Scollan, Christina Yung, Tugba Suzek, Workshop on Integration of Diverse Biological Data Center for Discrete Mathematics and Computer Science, Rutgers University, June 21-22, 2001 [PPT]

"Multi-Scale Modeling of the Heart", Society for the Industrial Application of Mathematics, Interfaces Among Information technology, Sensing Sciences and Biological Systems I.San Diego, CA, July 10, 2001 [PPT]

"Intracellular Ca2+ Cycling and Control of Action Potential Duration: Analyses Based on an Integrative Model of the Cardiac Ventricular Myocyte Incorporating Local-Control of JSR Ca2+ Release", Raimond L. Winslow & Joseph L. Greenstein, Workshop on Vertical Integration in Biology: From Molecule to Organism, Isaac Newton Institute for Mathematical Sciences University of Cambridge, Cambridge, UK, Sept. 24-28, 2001 [HTML] [PPT]

"Role of accessory proteins in cardiac action potential regulation: an integrative method for analyses,", Reza Mazhari, H. Bradley Nuss, Eduardo Marbán, Raimond L. Winslow. Annual Meeting of the Biomedical Engineering Society 2001 Sheraton Imperial Hotel, Durham, NC, Oct. 4-7, 2001 [HTML] [PPT]

"Probing the Role of Excitation-Contraction Coupling Properties on the Ventricular Action Potential", Joseph L. Greenstein and Raimond L. Winslow. Annual Meeting of the Biomedical Engineering Society 2001 Sheraton Imperial Hotel, Durham, NC, Oct. 4-7, 2001 [PPT]

"Research Directions, Challenges and Applications in the Field of Genomics", Raimond L. WInslow. Annual Meeting of the Biomedical Engineering Society 2001 Sheraton Imperial Hotel, Durham, NC, Oct. 4-7, 2001 [PPT]

"Gene Expression in End-Stage Dilated Cardiomyopathy", Raimond L. Winslow, Michael Bober, Paul Delmar, Gordon Tomaselli, Mark Boguski. Semi-Annual Review Meeting of the HOPGENES-PGA Nov 20, 2001 [HTML] [PPT]

"A Heart Failure Knowledgebase Combining Experimental Data with Tools for Integrative Biological Modeling", Raimond L. Winslow, Patrick Helm, William Baumgartner Jr., Tilak Ratnanather, Srinivas Peddi, Elliot McVeigh and Michael I. Miller. The Novartis Foundation Symposium on In Silico Simulation of Biological Processes University College, London, Nov 30, 2001 [HTML] [PPT]

"Reconstructing the Heart", IBM SUR Grant Review (Scollan)June 1, 2000 [PPT] [HTML]

"Calcium Cycling and Control of Action Potential Duration in Cardiac Myocytes", Computational Modeling of Biological Systems: From Gene to OrganHilton Head, South Carolina, Feb 23-26, 2000 [HTML] [PPT]

"Integrative Modeling of Cardiac Arrhythmia: A New Tool for Relating Altered Gene Expression to Cell and Tissue Function", Research Genetics, Inc., Huntsville, AL, March 2, 2000 [HTML] [PPT]

"Computational Models of the Failing Heart: Relating Altered gene Expresion to Myocyte Function", Division of Bioengineering, MIT, May 4, 2000 [HTML] [PPT]

"Whole-Heart Models of Cardiac Fibrillation", NASPEMay, 2000 [HTML] [PPT]

"Progress Report: Collaborative Research With IBM", IBM SUR Grant Review (Winslow)June 1, 2000 [PPT] [HTML]

"Modeling Effects of Stochastic Ion Channel Gating on Cardiac Cell Dynamics", IBM SUR Grant Review (Greenstein)June 1, 2000 [PPT] [HTML]

"Hierarchical Models of the Heart", National Library of Medicine Mtg on Modeling and Simulation in Medicine: Towards an Integrated FrameworkJuly 20-21, 2000

"Computational Model of Heart Failure: Relating Altered Gene Expression to Myocyte Function", Rosetta Inpharmatics, IncSeattle WA, Sept 7, 2000 [HTML] [PPT]

"Modulation of the Cardiac Ventricular Myocyte Action Potential by Intracellular Calcium", BMES 2000: The PhysiomeSeattle, WA, Oct. 12-14, 2000 [HTML] [PPT]

"Computational Modeling of Short-Term Interval-Force Relations in Single Cardiac Myocytes", BMES 2000: Mathematical and Computational Modeling in the Mechanics of CellsSeattle, WA, Oct. 12-14, 2000 [HTML] [PPT]

"Combining Stochastic and Deterministic Methods to Simulate Local Control by Diadic Ca2+ During a Ventricular Action Potential", BMES 2000: The PhysiomeSeattle WA, Oct. 12-14, 2000 [HTML] [PPT]

"Computational Biology of the heart", The Burroughs Welcome Program in Computational BiologyJohns Hopkins University, November 15, 2000 [HTML] [PPT]

"Computational Modeling of the Failing Myocyte: A Tool for Relating Altered Gene Expression to Function", Department of Biomedical Engineering, The University of Virginia, November 17, 2000 [HTML] [PPT]

"Mechanistic Analysis of MiRP1-HERG Functional Interactions in HEK293 Cells", Annual Meeting of the American Heart AssociationNovember, 2000 [HTML] [PPT]

"Integrative Modeling of Biological Systems", Center for Imaging Sciences, The Whitaker Biomedical Engineering Institute, December 4, 2000 [HTML] [PPT]

"Integrative Modeling of Biological Systems: Relating Altered Gene Expression to Cell and Tissue Function", Department of Mathematical Sciences, The Johns Hopkins University Whiting School of Engineering, December 6, 2000 [HTML] [PPT]

"Integrative Modeling of Cardiac Arrhythmia: From Genes to Function", 17th Annual Houston Conference on Biomedical EngineeringHouston TX, February 11-12, 1999 [HTML] [PPT]

"Modeling the Functional Consequences of Altered Gene Expression in End-Stage Heart Failure", National Center for Biotechnology Information, Computational Biology GroupBethesda MD, June 16, 1999 [HTML] [PPT]

"Mapping and Modeling Structure and Function of the Heart", Bioinformatics SeminarsDepartment of Pathology, The Johns Hopkins University School of Medicine, June 18, 1999 [HTML] [PPT]

"The Cellular Pathophysiology of Heart Failure: An Integrative Approach", Mathematical Research Branch, NIDDK-NIH, Bethesda, MD, June 23, 1999 [HTML] [PPT]

"Computer Modeling of Arrhythmia in Heart Failure", AHA Scientific Conference on Molecular, Cellular, and Integrated Approaches to the Failing HeartSnowbird Conference Center, Salt Lake City, Utah, Aug 18-22, 1999 [HTML] [PPT]

"Pathological and Pharmacological Influences on Electrical Activation and Recovery in the Heart", 1999 Physiome Symposium: The Integrated Biology of the HeartUniv. Wash.Seattle, Sept. 9-11, 1999 [HTML] [PPT]

"Integrative Modeling of Cardiac Arrhythmia: Relating Gene Expression to Cell and Tissue Function", First Joint BMES/EMBS ConferenceAtlanta, Georgia, October 13-16, 1999 [HTML] [PPT]

"Excitation-Contraction Coupling: Quantitative Models", 72nd American Heart Association Mtg.Atlanta, Georgia, Nov. 8-10, 1999 [PPT]

"How to Model Cardiac Electrical Activity", 72nd American Heart Association Mtg.Atlanta, Georgia, Nov. 8-10, 1999 [HTML] [PPT]